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Patients who discontinued a GLP-1 retained a similar protective association in both subgroups (18% lower risk for alcohol, 24% lower risk for non-alcohol)

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The use of both therapeutic groups, the established metformin and the newer AOMs, in combinational and intermittent regimens seems to be a reasonable option that needs more research attention in this population

A well-designed study that directly compares the effects of tirzepatide to retatrutide on specific endpoints (e.g., body composition, hepatic fat, inflammatory markers) would provide invaluable data to the scientific community