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10.1196/annals.1320.016 33

Although the intraperitoneal administration of exendin 939 did not cause adverse hyperthermia effects, a critical aspect of developing TRPV1 antagonists is minimizing interference with TRPV1 activation by protons and hence identifying mode-selective antagonists 32

Ethics approval NESDAs research protocol was approved by the ethical review board of each participating research center in Amsterdam, Leiden, and Groningen (METC number 2003-183)

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This protects it through digestion

Not all people show the same response, and the effect is typically acute (short-lived during and shortly after a meal)