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Nat Chem Biol 10:917 Hwang C, Sinskey AJ, Lodish HF (1992) Oxidized redox state of glutathione in the endoplasmic reticulum
The 2.5 mg dose is better called the low-dose starter, because it is the labeled start and now has short direct non-diabetic data behind it. Microdosing has been used for tolerability testing, metabolic-marker support, step-down protocols, and maintenance, not for proven long-term obesity outcomes
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Sallam M, Al-Mahzoum K, Eid H, Assaf AM, Abdaljaleel M, Al-Abbadi M, et al
Some early work reported favorable effects on fat metabolism, while larger later trials did not produce the weight loss outcomes needed for approval
For people listening, these are studies that are obviously flawed because they're not establishing causality
