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GLP-1 agonists, which primarily target extrahepatic mechanisms to ameliorate metabolic disorders, when used in conjunction with resmetirom, focusing on intrahepatic mechanisms, offer a complementary approach in the management of MASH and liver fibrosis

In an animal model, semaglutide demonstrated neuroprotective effects and improved cognitive function by inhibiting the release of inflammatory cytokines mediated by the NLRP3 inflammasome, a protein involved in regulating the innate immune system and inflammatory responses

High-fiber diets increase SCFA producers by 40% ( Faecalibacterium , Roseburia ) and improving metabolic parameters through GLP-1 secretion and hepatic gluconeogenesis suppression (Fu et al., 2022)