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Acid infusion enhances duodenal mechanosensitivity in healthy subjects

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Get started In clinical trials of the oral Wegovy (semaglutide) pill, participants taking the medication with diet and exercise achieved average weight loss of about 14%17% over ~64 weeks compared with ~2% with placebo

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However, attempts were also made to stabilise the GLP-1 molecule against DPP-4 and also to prevent its high renal clearance rate, which in itself would result in an IV half-life of 30 min