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Among 1961 patients without T2DM in the STEP 1 trial, the mean reduction in body weight from baseline was 14.9% and 2.4% at 68 weeks of follow-up in patients treated with semaglutide 2.4 mg and placebo, respectively ( P 1 weight reported during the 30-day window for a given follow-up time point, the closest weight to the time point of interest was utilized

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bioRxiv [Preprint] (2019)

For example, KPVs anti-swelling effects help keep the barrier-protective effects of Larazotide by reducing swelling-induced tight junction disruption, while Larazotides barrier protection reduces the passage of swelling stimuli that KPV must address