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The correlations between the change in these factors and eGFR at week 104 were derived from an MMRM using the bivariate model as specified by Thiebaut et al

J Gerontol Biol Sci Med Sci

Although data on HR were not provided in most studies of twice-daily exenatide, HR elevation was generally more apparent in the GLP-1 RA treatment arms, compared with the comparator arms (Table 2)

The results of major trials are summarized in Table 1

Briefly, islets were incubated overnight in full media containing 1 M thapsigargin 100 nM exendin-4 at 37 C and subsequently incubated in 25 M H 2 O 2 Substrate diluted in H 2 O 2 Substrate Dilution Buffer plus 1 M thapsigargin 100 nM exendin-4 in a final volume of 100 L for 3 hours at 37 C in a 5% CO 2 incubator

Longer storage increases degradation risk