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Early warning signs of dehydration that patients should monitor include: Thirst and dry mouth often the first noticeable symptoms Decreased urine output urinating less frequently or producing darker, more concentrated urine Fatigue and weakness feeling unusually tired or lacking energy Dizziness or lightheadedness particularly when standing (orthostatic symptoms) Headache may indicate fluid and electrolyte imbalance More severe dehydration signs requiring prompt medical attention include: Persistent vomiting or diarrhea inability to keep fluids down for more than 24 hours Significant orthostatic hypotension marked blood pressure drop upon standing with associated symptoms Confusion or altered mental status may indicate severe dehydration or electrolyte disturbance Decreased skin turgor skin that remains tented when pinched (though less reliable in older adults) Rapid heart rate compensatory tachycardia in response to volume depletion Patients should also be aware of symptoms that could indicate pancreatitis or gallbladder disease, which have been associated with GLP-1 medications

These scans were done before people started the low-calorie diet and again at the end of the 52-week treatment period

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