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Studies have shown that retatrutide, when used as an add-on therapy to existing diabetes medications, significantly reduces HbA1c levelsa key marker of long-term blood sugar control

There are no randomized controlled trials (RCTs) exploring this question, and only a small number of observational studies have assessed outcomes after treatment switch [13, 14]

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In analysis of TTO based on parameter distributions and the valid cases, the median TTOs (Interquartile range) for SSIBs associated with semaglutide, liraglutide, dulaglutide, and exenatide were 15.5 (0.524.25, n = 18), 9.5 (0.561.5, n = 19), 35.5 (6.560.5, n = 11), and 2.5 (1.5169.5, n = 4) days, respectively (albiglutide was not included in the TTO analysis due to insufficient data)

It is important to note that Phase 2 trials typically exclude participants with significant cardiovascular disease, which limits the generalisability of these safety findings to higher-risk populations

No immediate or predictable energy benefit has been established