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Semaglutide acts like just one hormone, GLP-1

Fifty-eight patients with ST-segment-elevation MI and thrombolysis were randomized to receive either saline (n = 40) or exenatide (n = 18, 10 g SC and 10 g as an IV bolus 5 min before the onset of reperfusion plus 10 g SC twice daily on the following 2 days) to evaluate whether this GLP-1R agonist could reduce the area of necrosis

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Dulaglutide BNF monograph

Neither is acceptable when dealing with an expensive medication

Trying a lower dose while monitoring weight and appetite gives you data about your minimum effective dose