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Long-term structural outcomes, including cartilage preservation and delayed joint replacement risk, still require further study

Among the available GLP-1 RAs, relatively few have been shown to be CNS penetrant

Exendin-4 reverses biochemical and functional alterations in the bloodbrain and bloodCSF barriers in diabetic rats

Regulatory changes and clinical evidence over the past decade have shifted this perspective, yet many BCBS plans retain older coverage rules that require additional justification before approving GLP-1 therapy for weight loss

All participants were adult males, nonsmokers, and not exposed to monoamine-acting drugs