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The authors propose here the new 5R principle, which considers the R ight species, R ight place, R ight time, R ight level, and R ight target. Erythrocytes are organelle-free cells that do not possess mitochondria and peroxisomes

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Anatomical studies suggest the following pathways: the posterior auricular artery (branch of the external carotid) and the occipital artery supply the mastoid and nearby tissues