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In Phase 2 clinical trial (NEJM, 2023), participants on 12 mg dose lost up to 24% body weight over 48 weeks the best result among all weight loss medications

Meet Your Medication: Semaglutide & Tirzepatide What is GLP-1

Inducible nitric oxide synthase activity mediates TNF--induced endothelial cell dysfunction

( 1 ) Originally approved to treat type 2 diabetes, researchers began creating more targeted versions of GLP-1 medications after it was found that diabetes patients taking the medication often lost weight, sometimes without even intentionally trying

Jeppesen PB, Gilroy R, Pertkiewicz M, Allard JP, Messing B, OKeefe SJ

2025 Jan 9;20(Suppl 6):e088069