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These cytoprotective effects extend beyond the GI tract to include protection against hepatotoxicity (liver damage), nephrotoxicity (kidney damage), and neurotoxicity in various animal models

According to Matthias Karst, M.D

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For patients who have a clear clinical goal and a protocol that matches it, committing to three cycles upfront is both the more economical and the more clinically sound decision

HNE up-regulates the expression of inducible cyclooxygenase (COX-2) and PAI-1 [131] and down-regulates the expression of adiponectin [119, 132]