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62 A number of our results, in both AP and CP models, are consistent with the conclusion that GLP-1Rs are expressed in activated PSCs and expression is increased over normal pancreas

Recently, through the engagement of their respective receptors, studies have shown that GIP and GLP-1 have a synergistic effect on appetite and body weight when the peptides are combined in pharmacology [6, 8], but the exact mechanisms underlying the enhanced weight loss exhibited by GIPR/GLP-1R co-agonism are still to be elucidated

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Despite extensive evidence for GLP-1R's neuroprotective and anti-inflammatory effects, fundamental gaps remain in understanding how these responses are orchestrated at the cellular level

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Data are presented as the means SEM, analyzed by unpaired Students t test with Welchs correction