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[11] [12] History and research [edit] Research in the early 1960s showed that in rats, administration of -MSH caused sexual arousal, and work on this continued in many labs up through the 1980s, when scientists at the University of Arizona began attempting to develop -MSH and analogs as potential sunless tanning agents, and synthesized and tested several analogs, including melanotan-I and melanotan II
Thyroid Tumors There have been reports of thyroid tumors, including medullary thyroid carcinoma (MTC), in patients using certain GLP-1 drugs
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Interestingly, higher incidence of diabetic retinopathy (DR) complications was noted in patients taking semaglutide (3.0%) compared to placebo (1.5%) in clinical trials, with greater risk in those with a history of DR [32]
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