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and/or CAD with ischemia documented by stress test with any imaging modality
The condition creates a frustrating cycle where insulin resistance promotes weight gain, and weight gain worsens insulin resistance and hormonal imbalance
Patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 are not candidates
Clinical evidence shows that people using semaglutide typically lose between 10 and 22 percent of their starting body weight, though individual results vary based on genetics, dosing consistency, and lifestyle factors
It can also block the inflammatory mechanisms in cells and animals with rheumatoid arthritis
However, nearly all data come from lab and animal studies rather than controlled human trials, so claims about systemic hormone changes warrant caution
