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10.1016/s1535-6108(04)00115-1 53 MuthukumarK.RajakumarS.SarkarM

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These results suggest that metformin may serve as a promising therapeutic agent for alleviating OA pain and slowing the progression of OA in MIA-induced mouse model, which is consistent with the results of a previous study 42

This was also shown for subjects with both type 2 diabetes and renal impairment based on data from clinical studies (Figure 3)