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This leads to decreased peripheral and central 5-HT levels, impaired receptor function, reduced concentrations of tryptophan and 5-HT (232), worsened symptoms of affective disorders, elevated levels of tryptophan catabolites (233, 234), and increased concentrations of toxic metabolites in the CNS (235)

Some of the most encouraging findings included reversal of some measures of cognitive decline, a significant condition in people with HIV, and also improved physical strength and other hallmark defects, Sekhar said

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These areas remain the focus of laboratory and preclinical research aimed at advancing scientific understanding of peptide biology, cellular signaling, and molecular pharmacology