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They sit near the top of the evidence hierarchy, just below meta-analyses (which combine multiple RCTs)

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Sandy Field, PHD Table of Contents 1 Introduction Summary and Quick Facts for Chemotherapy Cancer chemotherapy involves treating cancer with drugs that impair the ability of malignant cells to grow and divide

Int J Biol Macromol 112:929936 Zhu H, Itoh K, Yamamoto M, Zweier JL, Li Y (2005) Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury