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According to the working model, these cysteine residues may undergo chemical modification/remodeling including trisulfide bond formation and/or related reactions, resulting in a regional (minor, but effective) structural alteration that enhances c-met binding and the nitration resistance of Y198-HGF

The Eli Lilly pipeline suggests this direction

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Drugs that block intrinsic and acquired nutrient addiction may promote the susceptibility of cancer cells to ferroptosis [16,57]
