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The PNP 1-10-0.05 Sema-1.8 mg/mL formulation similarly lowered glucose levels with an average reduction of about 68 mg/dL, though with greater inter-animal variability

Some diets can be too restrictive and unsustainable

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It supplies the mechanistic and directional rationale for the whole compound class, but it is not a human trial and does not establish a human dose

A substantially greater proportion of participants treated with semaglutide 2.4 mg achieved 5% weight loss than those receiving placebo (68.8% vs 28.5%).[7] 3

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