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Start low (3 to 5 grams a day) and titrate up slowly to avoid bloating, advises Reisdorf
The Phase 3 protocols incorporated a more gradual titration scheme designed to improve tolerability and reduce early discontinuations, an approach consistent with the dose-escalation strategy used successfully for injectable GLP-1 agonists
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Tesamorelin has the only direct human RCT evidence for visceral fat reduction, albeit in an HIV-lipodystrophy population
10.1016/j.ygcen.2017.08.008 76
It is classified as an unapproved drug and is on the U.S
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