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The expression of MC 1 has also been detected in tissue samples, although the cellular localisation specifically on fibroblasts has not always been fully inferred, as MC 1 is highly expressed in melanocytes and other cell types found in complex tissues
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Neoseptins, small molecules with no relationship to the structure of LPS, were shown to bind to the TLR4-MD2 complex in such a manner that two drug molecules trigger a conformational change similar to that elicited by an authentic LPS molecule
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