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aeruginosa mutant strain deficient in both gshA and gshB showed a 4-fold and 8-fold increase in sensitivity to hydrogen peroxide and superoxide, respectively, suggesting antioxidant defense of GSH on antibiotics

Overdoing it can occasionally lead to side effects like nerve irritation (with too much B6), skin flushing (from high-dose B3), or digestive upset

Miligkos M, Bannuru RR, Alkofide H, et al

and the translocation of TRAF-6 into the nucleus (following the interaction of cyclosporine with TRAF-4), which causes TRAF-6-induced ECSIT breakdown and fosters the formation of oxidative species

2009 Feb;47(2):101-11

Metal-Mediated Signaling: Delivers bioavailable Cu to copper-dependent enzymes and pathways (e.g., lysyl oxidase family) that participate in cross-linking and tissue architecture