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And for patients with obesity, these medications can be lifesaving

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Trial data show an average increase of about 2.7 to 3.2 beats per minute in some studies, and real-world program data report a slightly higher proportion of people reporting increased heart rate on semaglutide versus not on it (for example, roughly 16 percent versus 11 percent after two years in an extensive registry analysis)

Approved Uses and Current Clinical Evidence in the UK Neither cagrilintide nor retatrutide is licensed by the MHRA or EMA