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Losing significant weight improves health markers, reduces risk of serious diseases, and often decreases spending on other medications or health conditions related to excess weight

Control of renal solute excretion by enteric signals and mediators

This leads to not only greater weight loss but also more significant improvements in metabolic health , including better insulin sensitivity and fat burning

BMC Genomics 13:187

Participants who had received the placebo up to week 80, achieved an average of 19.2% reduction in body weight at 104 weeks after switching to the maximum tolerated dose of retatrutide

10.1161/HYPERTENSIONAHA.116.08184 128 WangJ.LiR