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8-12 hours IM) Preferred by 64% of patients who've tried both Intramuscular (into deltoid or vastus lateralis, using a 22-25 gauge, 1-inch needle): 41% report injection-site soreness Faster absorption More difficult self-administration for some sites (deltoid requires non-dominant arm injection) Preferred by 36% of patients who've tried both The efficacy difference is minimal

The SUSTAIN trial series, which established semaglutide's safety and effectiveness, used a once-weekly protocol exclusively

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Fat Loss & Metabolic Improvement Sustained GH elevation keeps the body in a fat-burning metabolic state more consistently