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ROS induce inflammation by increasing the production of pro-inflammatory cytokines, especially IL-1, IL-8, and TNF- (176, 177)
In tau transgenic mice we saw improvements in brain structure and function by reducing senescent cell burden by 30% with an intermittent treatment strategy (35), which is consistent with preclinical studies on other models of aging and/or disease (37, 45, 46, 101103, 108112)
In db/db mouse models, AANG treatment preserved renal architecture, improved kidney function, and promoted pancreatic -cell proliferation, thereby enhancing insulin secretion and restoring glucose and lipid homeostasis (221)
Duration guided by mechanism timeline: Acute healing mechanisms (Thymosin Beta-4 wound closure) show effects within days to weeks, treatment courses 4-8 weeks typical
M.DanielianL
Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the mice
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