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The dietary principles are the same regardless of which specific medication you are on, though appetite suppression varies in intensity
A prospective trial assessing clinical outcomes across different stages of fibrosis in MASLD showed parallel increases in liver adverse outcomes and all-cause mortality with fibrosis severity
& Zuker, C
88, 89 The Morris hepatoma, which was also suppressed by insulin, 90 was stimulated by acute fasting, 91 and it was later discovered that linoleic and arachidonic acid released from adipose tissue were the main substrates promoting tumor growth
For this reason, modern pharmacological research has focused on therapies capable of addressing several metabolic abnormalities simultaneously instead of targeting blood glucose alone
Given the limitations of current therapies including nucleos(t)ide analogues and pegylated interferon alpha, novel agents targeting functional cure are emerging
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