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Inhibition of food intake by hypothalamic PPAR activation is, however, not undisputed since hypothalamic viral-mediated overexpression of PPAR, or third ventricle administration of the PPAR agonist Rosiglitazone, has also been shown to increase food intake and body weight in rats 7

Oligo-Fucoidan improves diabetes-induced renal fibrosis via activation of Sirt-1, GLP-1R, and Nrf2/HO-1: an in vitro and in vivo study

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I do expect these numbers will increase with time and length of treatment