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ROS Scavenging and Gene Regulation: Oxidative stress upregulates the Microphthalmia-associated Transcription Factor (MITF), which acts as the primary on-switch for melanin production [5]
The time to maximum effect is determined by titration speed, not the medication itself
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Interestingly, endothelial nitric oxide synthase (eNOS) can also reduce DOX to its semiquinone form, enhancing superoxide formation and decreasing nitric oxide production
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