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While reduction of mSOD1 in motor neurons delayed disease onset and early disease progression, diminished mSOD1 levels in microglia sharply slowed later disease progression
varies with administration technique
ALS reversals: demographics, disease characteristics, treatments, and co-morbidities
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Although with some controversy, the accumulated evidence directly supports an age-related decline in the ability to respond to OS with the activation of the NRF2/ARE signalling pathway, thereby reducing the expression of its target antioxidant genes [327]
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