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The first is poly-agonist escalationthe progression from GLP-1 alone to dual and then triple or even quad receptor targeting

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Its important that this decision should be based on careful evaluation of multiple factors including individual response, tolerance, adherence to therapy, cost considerations, and most importantly, the patients overall safety

These medications can: Because insulin secretion is glucose dependent, GLP-1 medications generally have a lower risk of hypoglycemia when used alone compared with medications that stimulate insulin regardless of glucose levels

People with this variant were more likely to lose weight on GLP-1s

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