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Patients: A total of 9650 adult patients with established CV disease without CKD (56.7%), CKD only (13%), or both CV disease and CKD (27%) were randomized 1:1 to receive semaglutide tablets 14 mg (n=4825) or placebo (n=4825) once daily, both in addition to standard-of-care treatments for glycemic control and CV risk factors including blood pressure medication, lipid-lowering agents, and antiplatelet/anticoagulant therapy
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10.1016/j.molimm.2018.10.016 122 HuangJ.-Y.PengS.-F.ChuehF.-S.ChenP.-Y.HuangY.-P.HuangW.-W.et al (2021)
cyclisation broadens agonist activity across MC1R, MC3R, MC4R and MC5R and increases resistance to proteolytic cleavage, giving the non-selective profile that makes it the usual positive-control agonist in receptor assays
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