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Nevertheless, the relatively low occurrence of MACE implies that the translation of ongoing research to the bedside would provide a safe therapeutic alternative to available anti-diabetics, with additional cardioprotective and vasculoprotective effects

Experimental investigations suggest that modulation of NNMT activity may influence cellular pathways associated with energy utilization, nutrient partitioning, and metabolic adaptation

Two authors (AM and SS) independently screened study titles and abstracts to ascertain eligibility for full-text assessment, with any discrepancies resolved through consultation with a senior author (HR)

Orskov C, Rabenhj L, Wettergren A, Kofod H, Holst JJ

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