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Besides, the major organs were collected for H&E staining to evaluate the tissue damages, which showed no obvious pathological changes for all organs (Supplementary Fig

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For example, someone who begins a GLP-1 medication in January may notice increased shedding in March or April

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[33, 34, 35, 36] Mechanism: Typically pre-renal, occurring in the setting of volume depletion from GI losses (nausea, vomiting, diarrhea, reduced oral intake) More frequently seen at higher, obesity-level doses Although generally reno-protective long term, post-marketing data describe acute rises in creatinine following days to weeks of significant GI symptoms Risk factors: Underlying chronic kidney disease Concomitant use of ACE inhibitors, ARBs, diuretics, or SGLT2 inhibitors ED Management: IV fluids Hold GLP-1 and contributing medications Usually reversible with supportive care Future Directions GLP-1 receptor agonists are rapidly evolving beyond their original indications in diabetes and obesity

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18 At the same time, delayed mortality could enable insurers to hold investment earnings for longer periods of time

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