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Althea Med J (2016) 3(3):44651

Current proposed mechanisms of biguanides include glycolysis simulation in tissues, reducing glucose absorption from GIT with increased glucose to lactate conversion, reduced hepatic and renal gluconeogenesis, in the GI tract and reduction of plasma glucagon levels [123]

But clinical data, dosing, and understanding of the broader effects in humans lacks study

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Explain amino acid co-benefits (metabolic support, muscle synthesis)