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recently showed that direct GPx4 overexpression in the cellular models (A549, H460 and H1299 and H23) of non-small cell lung carcinoma (NSCLC) prevented the radiation-induced lipid peroxidation and, in turn, contributed to radioresistance by blocking the ferroptosis mode of cell death [56]

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Not only tirzepatide displayed a 20-fold lower potency in cAMP generation compared with native GLP-1, but also showed a signaling bias towards cAMP instead of beta-arrestin recruitment [39, 42]

The study focused on children aged 811 years and adolescents aged 1217 years who had a body mass index (BMI) in the 95th percentile and no prior diagnosis of type 2 diabetes

Purity was measured by HPLC with UV detection coupled to mass spectrometry, and bacterial endotoxin was tested using a Limulus Amebocyte Lysate assay under validated conditions

Although definitive randomized trials specifically designed to test proteins, amino acids and micronutrients supplementation in this population are still lacking, data from clinical trials, real-world studies, and cross-sectional analyses support the adoption of a preventive and structured nutritional framework in clinical practice