Rare cases of allergic contact dermatitis have been described with prolonged copper exposure, so persistent or worsening inflammation should prompt discontinuation and medical evaluation
Drug Interactions: Certain medications, like metformin and stomach acid reducers (PPIs), can interfere with B12 absorption from food, which may increase the need for injections
The gut microbiome and obesity (in Eng)
The disease is called pernicious ( deadly ), because before B12 shots were available, people had no choice but to die
On a molecular level, AOD-9604 is compact enough to achieve good solubility in aqueous diluents yet large enough to retain the structural motif needed for its adipocyte-targeting activity
For providers, having a potent oral option improves long-term adherence for patients who are averse to subcutaneous injections