If an individual lacks a functional liver enzyme called FMO3, they cannot degrade TMA into a non-smelly chemical form, trimethylamine oxide, or TMAO
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For responders at Week 12 who were re-randomized to treatment withdrawal (i.e., placebo), the median time to relapse (sPGA 3) was 164 days in the integrated trials
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Treatment with sulforaphane produces antinociception and improves morphine effects during inflammatory pain in mice
Not approved by the FDA or any regulatory authority