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Allergy 64, 183193 (2009)

This water soluble antioxidant compound is an unusual peptide in that the peptide bond between the glutamate residue and the cysteine residue is formed with the -carboxylate group of the former rather than the -carboxylate group

It has exceedingly low solubility, and it is not absorbed from the GI tract

The charts below compare different frequency protocols and their typical outcomes

Those with diseases that affect the gut, such as Crohns disease or celiac disease, are also at risk ( Summary Those at greatest risk of vitamin B12 deficiency are vegans and vegetarians, who get little to no B12 from the diet