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Several complex signal transduction pathways and cellular processes have been implicated in APAP hepatotoxicity, including those involving c-Jun N-terminal kinase, Nuclear factor E2-related factor 2 (Nrf2), p53, endoplasmic reticulum stress, autophagy, and sterile inflammation (Chowdhury et al

doi: 10.2337/db24-0861 45

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Approved Ingredients, Unapproved Products, and Patient Risks Choosing an FDA-approved drug means it has gone through a lot of checks for safety and if it works well

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