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3 Synergistic pathogenic mechanisms of ferroptosis in DR 3.1 Vicious cycle mechanism of oxidative stress-BRB injury-ferroptosis Oxidative stress is defined as an imbalance between reactive oxygen species (ROS) and the endogenous antioxidant defense system, and the retinal tissue and cellular damage it mediates serves as a core pathological driver of diabetic retinopathy (DR) progression (151)

It is made up of three amino acids, namely glutamine, glycine, and cysteine

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