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Tirzepatide's dual GIP/GLP-1 mechanism may also produce a different GI side-effect profile in individual patients
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Strinic D, Lovric-Bencic M, Buljat G, et al
Some researchers argue that pulsatile peptide delivery, with peaks and troughs in plasma concentration, may produce different receptor signaling patterns than the sustained exposure from weekly injections
Koob, 2010
Think of it as opening the drainage valves on stored body fat
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