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If levels don't respond to standard supplementation, investigate possible MTHFR polymorphisms, malabsorption conditions like celiac or Crohn's disease, or potential medication interactions

AOD-9604 Peptide Synthesized and Lyophilized in Canada by Koi Peptides Domestic Synthesis at a Canadian Facility Assembly of the 16-residue chain is carried out by solid-phase peptide synthesis at a Canadian manufacturing partner, with the Cys7-Cys14 disulfide bond formed during the oxidation step before final purification

VidalAlaball J, Butler C, CanningsJohn R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A

The trial was 12 weeks

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Cardiac, metabolic, and liver labs published preclinical work tracked