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Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance

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Phase 2 trial data showed a mean body weight reduction of approximately 24% at the highest dose (12 mg) over 48 weeks, though Phase 3 confirmation is required

According to the cited figure 3[14], the increase of NADPH concentration from 2,5 mM [1] up to 10 mM also increases the velocity of GR and the GSH reserve levels, that are increased from 10 mM up to 100 mM, in such a way to always saturate GP activity

It is also a prescription-only medication