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There are a number of reasons for the frequent use of this therapy: from a pathophysiological point, the metformin/DPP-4 combination leads to higher GLP-1 concentrations compared to a therapy with a DPP-4 inhibitor alone (75)
Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a bloodbrain barrier model
Feng X, McDonald JM
Many protocols don't use daily administration
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