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The consequence that actually shows up on a bench is this: in a serum-containing medium, the free fraction of added IGF-1 LR3 is much higher than the free fraction of an equal mass of native IGF-1, and it is far less buffered, because the binding-protein reservoir that would normally absorb an excess and release it slowly is largely not engaging with this molecule

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That means you have no way to verify your treatment is safe

This warning is based on findings in rodent studies where these drugs caused thyroid C-cell tumors (medullary thyroid carcinoma) at clinically relevant exposures

doi:10.1245/s10434-017-6107-9

Research Use Only This product is intended solely for in vitro research and laboratory use