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The key shift we need The question is no longer: Can patients stop GLP-1s without regaining weight? It is: Which patients can taper, how slowly, with what lifestyle support, and with what monitoring? Until trials are designed to study deprescribing strategies, weight regain after abrupt withdrawal should not be framed as inevitability
Combined with biomarkers (glucose, insulin, inflammatory markers), genetic context helps guide whether dose optimization, lifestyle modification, or alternative approaches may be most beneficial
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